Influence of Wet–Dry Cycling on the Self?Assembly and Physicochemical Properties of Model Protocellular Membrane Systems

Wet-dry cycles are hypothesized to facilitate fundamental steps towards the emergence of life on prebiotic Earth. Multiple wet–dry have been demonstrated promote biopolymer formation. However, effect recurring wet-dry self-assembly and physicochemical properties model protocellular membranes remains somewhat obscure. Towards this end, we evaluated structural chemical stability composite protocell membrane systems composed single chain amphiphiles, under cycles. The change in properties, size encapsulation was also investigated. Model were found reassemble into vesicles even over multiple cycling. cycling induced compositional changes membranes, leading their properties. increase vesicular calcein. This work outlines how early Earth could helped formation entities evolution